Mechanism of Action of Aromasin Exemestane & How to Use It
Manufactured by Pfizer, Aromasin is the best and most potent steroidal aromatase inhibitor available in the market for the treatment of early and advanced breast cancer and breast tumors in postmenopausal women. With the active ingredient Exemestane, this medication is the sole aromatase inhibitor that does not make a negative impact on one’s cholesterol profile. Other medicines in the same class like Arimidex and Femara are known for causing damage to lipid profiles, thereby elevating bad cholesterol or Low Density Lipoprotein (LDL) and lowering good cholesterol or High Density Lipoprotein (HDL). Another amazing fact in favor of Aromasin (Exemestane) is its less reported side effects by users even though it is the most powerful among all anti aromatases.
Mechanism of Action
People often draw similarity between anti aromatases (Aromasin, Arimidex, and Femara) and anti estrogens (Nolvadex). However, there is a big difference in the mechanism of action of these two classes of drugs. Anti estrogens are normally weak estrogens that connect to the estrogen receptor locations in the body such as the breast area and nipple. As a result, they inhibit the bad estrogens from getting attached to these locations.
On the other hand, anti aromatases like Aromasin (Exemestane) inhibit the development of estrogen hormone in the body to begin with. They accomplish this task by arresting the enzyme aromatase that carries out the conversion of testosterone to estrogen. Consequently, lower amounts of estrogen are produced and circulated in the blood. Truly speaking, Aromasin addresses the problem straight from its source.
How to Use Aromasin (Exemestane)
The dosage and administration of Exemestane is quite simple to understand. You need to take one 25 mg tablet orally, once daily. Take the medicine with food, preferably after a meal. The duration of the treatment is generally determined after discussing with your doctor. However, you may have to continue the drug up to 5 years. The best thing will be to follow the instructions of your healthcare provider. You should also go through your prescription label. Adhere to the dosage, as directed by your physician. Never try to take larger doses or for longer period than prescribed. Perform regular blood tests to detect the harmful effects of the medication on your body. All the scheduled appointments with your doctor must be obliged.
Sticking to the same dosing time everyday reduces the chance of a missed dose altogether. In case of an accidental missing of a dose of Aromasin, take the missed dose as soon as you come to know about it. If it is already time for the next dose, skip the missed dose and get on with your regular dosing schedule. Taking additional dose to make up for the missed one is strictly prohibited.
Overdoses of Aromasin (Exemestane) necessitate immediate medical help. Contact your healthcare provider right away or visit a nearest hospital. Symptoms of overdose may include nausea, vomiting, stomachache, or blood in your stools.